Sr. Research Associate II - Neuroscience Histology/Ex Vivo Biomarker
Company: Takeda Pharmaceutical
Location: Chula Vista
Posted on: August 4, 2022
Job Description:
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that all information I submit in my employment application is true
to the best of my knowledge. Job Description About the role: The
Sr. Research Associate II will independently contribute to the
development of neuroscience-relevant biomarker assays and provide
histology support to portfolio programs within the Neuroscience
Drug Discovery Unit. This includes; preparation of rodent brain
tissue for histology, immunohistochemistry, immunofluorescence, in
situ hybridization/RNAscope and other methods to evaluate
biological targets in brain tissue, confocal microscopy and
quantitative analysis (manual or automated). Expertise in ex vivo
assays such as western blot, ELISA, PCR a plus. This position
requires agility and flexibility to switch between independent work
and collaboration with a high-performing close knit team. The ideal
candidate will provide complex problem resolution within project
scope. Join Takeda as a Sr. Research Associate II - Neuroscience
Histology/Ex Vivo Biomarker , based in San Diego, CA.How you will
contribute: ACCOUNTABILITIES
- Works independently to conduct multiple complex analyses of
biological targets in brain tissue, requiring preparation and
sectioning of brain tissue via cryostat or other methods,
immunohistochemistry/immunofluorescence or other histology methods,
microscopy, quantitative assessment (manual and/or automated).
- Independently follows protocols, develops and validates novel
protocols/assays, and troubleshoots non-routine methods,
instrumentation and software issues.
- Expected to be highly organized, able to manage priorities and
set appropriate weekly workload for the ex vivo studies including
coordinating with project leaders to set acceptable timelines for
each project based on urgency and resource limitations.
- Communicate clearly with a variety of partners including in
vivo pharmacology team and other neuroscientists; works
collaboratively when required on study design and assay
development. Prepares and presents technical information and data
updates at project or departmental meetings as appropriate
- Independently keeps abreast of current Neuroscience literature
to increase knowledge base and implement improvements
- Keeps an accurate, comprehensible, concise notebook in
accordance with company policy
- Perform general lab support duties including preparation of
solutions and ordering supplies.
- Able to train junior personnel to perform studiesMinimum
Requirements/Qualifications:
- BS in a scientific discipline (or equivalent) with 6+ years
experience, or MS in a scientific discipline, or equivalent with 2+
years experience
- Expertise in rodent brain tissue preparation and use of
cryostat/vibratome/microtome required. Experience with human or
non-human primate brain tissues desirable.
- Expertise in immunohistochemistry/immunofluorescence and other
histological methods required
- Experienced in evaluating antibodies and developing PCR
probes
- Expertise in confocal or other microscopy
- Utilizes a battery of ex vivo assay technologies; qPCR, western
blot, immunoassays or other ex vivo tissue analysis methods
- Experience in immunoprecipitation and protein extraction
- Highly skilled in quantitative analysis of targets in brain
tissue, statistical analysis, graphing programs like Graphpad
Prism, PowerPoint presentations, Excel and software programs to
image tissues and analyze histological targets
- Familiarity with rodent in vivo methods (i.e. handling,
p.o.dosing), necropsy and sample collection procedures a plus
- Excellent written and verbal communication skills and possess
the ability to work independently as well as part of a tightknit
team
- Experience in drug discovery, particularly Neuroscience and
diseases of the central nervous system
- Ability to mentor junior scientists and interns
- Ability to design and interpret experiments collaboratively and
independently
- Ability to be agile and flexible- manage multiple tasks and
priorities to achieve desired goals
- Excellent attention to detailWhat Takeda can offer you:
- Comprehensive Healthcare: Medical, Dental, and Vision
- Financial Planning & Stability: 401(k) with company match and
Annual Retirement Contribution Plan
- Health & Wellness programs including onsite flu shots and
health screenings
- Generous time off for vacation and the option to purchase
additional vacation days
- Community Outreach Programs and company match of charitable
contributions
- Family Planning Support
- Flexible Work Paths
- Tuition reimbursementMore about us:At Takeda, we are
transforming patient care through the development of novel
specialty pharmaceuticals and best in class patient support
programs. Takeda is a patient-focused company that will inspire and
empower you to grow through life-changing work.Certified as a
Global Top Employer, Takeda offers stimulating careers, encourages
innovation, and strives for excellence in everything we do. We
foster an inclusive, collaborative workplace, in which our teams
are united by an unwavering commitment to deliver Better Health and
a Brighter Future to people around the world.In accordance with the
CO Equal Pay Act, Colorado Applicants Are Not Permitted to
Apply.EEO Statement Takeda is proud in its commitment to creating a
diverse workforce and providing equal employment opportunities to
all employees and applicants for employment without regard to race,
color, religion, sex, sexual orientation, gender identity, gender
expression, parental status, national origin, age, disability,
citizenship status, genetic information or characteristics, marital
status, status as a Vietnam era veteran, special disabled veteran,
or other protected veteran in accordance with applicable federal,
state and local laws, and any other characteristic protected by
law. Locations San Diego, CA Worker Type Employee Worker Sub-Type
Regular Time Type Full time
Keywords: Takeda Pharmaceutical, Chula Vista , Sr. Research Associate II - Neuroscience Histology/Ex Vivo Biomarker, Other , Chula Vista, California
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